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This limitation should be stated explicitly, not disguised, because it shapes what the paper can claim

The gene-editing technologies (such as CRISPR) include the delivery of CRISPR-Cas9 components, where nanoparticles transport the CRISPR-Cas9 system (Cas9 protein and guide RNA) to infected cells while shielding the components from nuclease degradation

Elliott EI, Miller AN, Banoth B, Iyer SS, Stotland A, Weiss JP

Radiation retinopathy may occur as a side effect

These substances include bacterial endotoxins (particularly lipopolysaccharide, LPS), whole bacteria, and damage-associated molecular patterns (DAMPs) released from injured intestinal cells