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Most available data are preclinical or derived from non-orthopaedic clinical contexts, and robust human orthopaedic trials were not identified

This study addresses how tick exosomal glycine-rich protein (GRP) secreted into the infectious saliva facilitates transmission of pathogens including Langat virus (LGTV, a tick-borne flavivirus) to the vertebrate host

The increased formation of superoxide and H 2 O 2 due to autoxidation of extracellular Hb, also results in the oxidation of the functional ferrous Hb to Fe(III)metHb (Equation 1)