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Inhibition of polyamine uptake potentiates the anti-proliferative effect of polyamine synthesis inhibition and preserves the contractile phenotype of vascular smooth muscle cells

the capacity to invade other organs and tissues, a process known as metastasis

Mol Biol Cell 2004;15:50015011

First, it has been established in PH models and clinical experiments that iron deficiency is strongly associated with poor outcomes in patients with PH, leading to inflammatory cell infiltration and right ventricular hypertrophy