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The incidence of DPN is associated with hyperglycemia and cardiovascular risk factors such as raised cholesterol, triglycerides, hypertension, obesity, and smoking, which can be modulated by early intervention

In spite of the failure in medical research, animal obervations help the roles of secretin in some social functions

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The role of constitutive COX-2 expression in areas of the nervous system, such as the hippocampus, hypothalamus, and amygdala, remains to be elucidated