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It has also been observed that the addition of exogenous MOTS-c increases the level of myocardial MOTS-c, which activates AMPK (33)

Evaluation of these three biomarkers was performed in urine samples from 24 control patients, one severe APAP overdose patient and 10 additional patients suspected of drug-induced acute liver injury (ALI) where eight of the 10 ALI patients were linked to APAP ingestion