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The redox active roGFP2 protein is oxidized by PE N-chloramines in vitro Previously, model N -chloramines such as taurine or lysine N -chloramines have been shown to oxidize various thiol-containing plasma proteins such as human serum albumin (HSA)

The X helix was recently resolved in a prefusion-stabilized ectodomain construct of HCMV gB 17 , showing an extra orientation, perpendicular to the position found in the postfusion conformation of gB 34

10.1161/ATVBAHA.120.315322 83

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In parallel, causal in vivo studies targeting key structural regulators of these contact sites, such as MFN2 and other tethering proteins, will be particularly informative for determining whether disruption of organelle interaction hubs directly contributes to mitochondrial dysfunction, metabolic imbalance, and functional ovarian decline