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ER signaling can inhibit ferroptosis by enhancing antioxidant defenses through NRF2 stabilization, GPX4 upregulation, and regulation of iron metabolism, or promote ferroptosis by activating NOX1 and increasing ROS production

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A further preferred embodiment is a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the nucleotide sequence of SEQ ID NO:1 beginning with the nucleotide at about the position of the 5 NT of ORF and ending with the nucleotide at about the position of the 3 NT of ORF as defined for SEQ ID NO:1 in Table I

10.1161/01.RES.0000259559.48597.32 Fielitz J, van Rooij E, Spencer JA, Shelton JM, Latif S, van der Nagel R, Bezprozvannaya S, de Windt L, Richardson JA, Bassel-Duby R, Olson EN: Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction

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