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Conversely, the STRENGTH trial (n = 13,078)using a carboxylic acid formulation of eicosapentaenoic acid plus docosahexaenoic acidwas terminated prematurely for futility (HR 0.99, 95% CI 0.901.09) ( These results suggest that not all omega-3 formulations are equivalent

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This dual mechanism allows for a more rapid and efficient delivery route of pharmaceutical agents to enter the brain and exert therapeutic effects (Figure 2)

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References Abdulghani AA, Sherr A, Shirin S et al (1998) Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study