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This rapid availability is crucial for detoxifying heavy metals or managing acute toxic exposure

Val/Met (A/G genotype) : A medium or intermediate COMTfalls in between, with moderately reduced enzyme speed

doi: 10.1053/plac.1999.0524 46 ShibuyaM

This initiates a cascade of physiological phenomena, including activation of pro-inflammatory cytokines, disruption of the bloodbrain barrier, production of reactive oxygen species, and mitochondrial dysfunction, ultimately resulting in cellular ischemia, damage, and apoptosis (Figure 3)