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Novel defects in collagen XII and VI expand the mixed myopathy/EhlersDanlos syndrome spectrum and lead to variant-specific alterations in the extracellular matrix

The medium coefficient of variation for each quantitative dataset is provided in each Supplementary Dataset legend

Preclinical investigations in aged animal models have reported that NNMT inhibition may: Influence activation of muscle-resident stem cells following injury Alter myofiber cross-sectional area and contractile properties Interact with NAD-dependent mechanisms implicated in mitochondrial quality and tissue resilience These findings support the use of 5-Amino-1MQ as a research tool for studying muscle regeneration, sarcopenia models, and age-associated changes in muscle physiology

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The corticosterone concentration generally increases during lactation, while the glucocorticoid concentration decreases gradually and significantly during the same period