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Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case-control study nested within the French E3N cohort

Methylcobalamin, while slightly less stable, remains safe and effective when handled properly in a clinical setting

Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production

Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates

These dosing considerations highlight that many observed effects reflect mechanistic potential rather than direct proxies for human exposure and which underscores the need for cautious translational interpretation