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Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)

Upregulation of miR-21 or interference with BDH2 expression enhanced TET protein activity, resulting in decreased DNA methylation of the BCL6 gene promoter, ultimately promoting BCL6 gene expression [26]

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Phosphoproteomic data analysis The analysis of phosphoproteomic data was generally followed as outlined in the paper introducing PhosR 51 , which employs a multi-step framework comprising two major components: the first component is the kinaseSubstrateScore function, which evaluates a given phosphosite by integrating kinase recognition motifs and phosphoproteomic dynamics, and the second component is the kinaseSubstratePred function, which combines the scores from the first component for predicting kinase-substrate relationships using an adaptive sampling-based positive-unlabeled learning method 90

They are beneficial for individuals with pernicious anemia, gastrointestinal problems, older adults with reduced B12 absorption, and those on vegan or strict vegetarian diets