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In the high-concentration Pi-induced VSMC calcification model, overexpression of PDK4 located in the mitochondria and cytoplasm increased the phosphorylation level of SMAD1/5/8 and promoted its nuclear translocation, enhancing the activity of Runx2 and ALP promoters downstream of Bone Morphogenetic Protein 2 (BMP2) through the BMP2/SMAD pathway, inducing VSMC osteogenesis

Metabolic effects of intra-abdominal fat in GHRKO mice

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