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In preclinical models, simultaneous deficiency in NAD+ and GSH is associated with accelerated mitochondrial dysfunction

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This was useful as a reductionist measure, because it allowed him to analyze the initiation and promotion periods separately

Disulfides are cleaved reductively by -mercaptoethanol, dithiothreitol, or TCEP, or oxidatively by performic acid reagents widely used in protein structure analysis

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