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Strategies that stabilize mitochondrial membranes, modulate BAX/BAK pore dynamics [83], or block downstream mtDNA sensing pathways [84] could inhibit inflammation without fully blocking apoptosis

Substituted alkyl refers to an alkyl group having from 1 to 5, preferably 1 to 3, or more preferably 1 to 2 substituents selected from the group consisting of alkoxy, substituted alkoxy, acyl, acylamino, aminocarbonylamino, acyloxy, amino, substituted amino, the substituted alkyl groups include halogenated alkyl groups and particularly halogenated methyl groups such as trifluoromethyl, difluromethyl, fluoromethyl and the like

The active constituent of Milk Thistle is a flavonoid known as silymarin, which is a potent antioxidant

(Wolffenbuttel BHR, Wouters HJCM, Heiner-Fokkema MR, van der Klauw MM

2023;83:1693709.e9 Narendra DP, Youle RJ