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Name: l acetyl carnitine depression alzheimer's disease Frontiers How Acetyl-L Carnitine Works |
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Mechanism of action in humans [edit] Steps [edit] Binding of the coenzyme NAD + Binding of the alcohol substrate by coordination to zinc(II) ion Deprotonation of His-51 Deprotonation of nicotinamide ribose Deprotonation of Thr-48 Deprotonation of the alcohol Hydride transfer from the alkoxide ion to NAD + , leading to NADH and a zinc-bound aldehyde or ketone Release of aldehyde

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