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COX-2 is highly expressed in most tumors and promotes tumor proliferation, migration and angiogenesis (106)

However, the clinical application of berberine is restricted because of its poor water solubility and low bioavailability

207,210 In PH models, CaSR targeting with calcilytics like NPS 2143 reduces RV pressure, hypertrophy, and fibrosis, suggesting a promising therapeutic approach