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Overall, the Panel judged that these findings provided some certainty that the balance between benefits and risks/burdens on average is relatively equal and that, similar to other oral treatments, oral PPS may benefit only a subset of patients not readily identifiable a priori

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In the U-shaped A 40 fibrils the 1 and 2 strands are staggered, and a for the U-shape geometry characteristic salt bridge D23-K28 connects chain (i) and (i+2) in L-fibrils, but chains (i) and (i-2) in DRI fibrils, see also Figure 8e in a later section of this paper

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