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Notably, many tumors also express functional lipoprotein lipase and can harvest fatty acids from triglyceride-rich lipoproteins via two routes: (i) lipoprotein lipase -mediated extracellular hydrolysis with subsequent uptake (e.g., via the CD36 receptor) and (ii) a non-catalytic bridging mode in which the lipase tethered to heparan-sulfate proteoglycans interacts with very low density lipoprotein receptor family pathways to internalize lipoprotein particles 14,15,16,17,18,19

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We also summarize the development of targeted delivery systems for some of these inhibitors

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