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MGO treatment in vitro leads to a downregulation of the insulin signaling pathway in primary astrocytes, through increased phosphorylation of the insulin receptor and insulin receptor substrate [115]

Sharma A, Wang J, Xu D, Tao S, Chong S, Yan D, Li Z, Yuan H, Zheng B (2020) Melatonin regulates the functional components of photosynthesis, antioxidant system, gene expression, and metabolic pathways to induce drought resistance in grafted Carya cathayensis plants

These coordinated molecular perturbations manifest physiologically as systemic glucose disposal deficits, compensatory hyperinsulinemia, and progressive advancement toward metabolic syndrome