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These results were consistent with the reports showing that M1 macrophages were protected from ROS-induced DNA damage as a result of increased expression of multiple antioxidant genes, such as superoxide dismutase 2 (SOD2) [95, 96]

Stress induction iRPE cells were exposed to FeCl 3 NTA (1 mM) or 4HNE (120 M) for 24 h, and TF (1020 mg/mL) was co-administered with the stress inducer