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Premature graying is often linked to hypothyroidism, heavy metal accumulation, drug use, excessive free radicals, and nutritional deficiencies

In this context, Du et al., noted loss of tissue resident macrophages in colon biopsies from patients with ulcerative colitis, that was accompanied by decreased superoxide dismutase 2 expression (an important antioxidant) in the macrophages [3]

Biochemistry, transferrin

Our novel NNMT inhibitors display excellent physical chemical properties (e.g., membrane permeability), selectivity, and cellular inhibitory activity against NNMT, concomitantly enhancing the levels of the cofactors SAM and NAD + that independently regulate cellular energy metabolism and epigenetic modifications

Additionally, FTMGL not only inhibits the pigment deposition through antioxidant activity, but also reduces MITF expression by modulating p38 and JNK in the cAMP-PI3K/Akt and MAPK signaling pathway, thereby inhibiting melanin synthesis in melanoma cells (Pudlarz et al., 2020) (Figure 2)