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At a glance, the table underscores the throughline of this entire comparison: none of these three compounds substitutes for another, because each is anchored to a different level of biological activity cellular, mitochondrial, and endocrine, respectively

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GLP-1 agonists like semaglutide help lower blood sugar levels by increasing the amount of insulin released by the pancreas and decreasing the amount of glucose produced by the liver, notes Chris Damman, M.D., clinical associate professor of Gastroenterology and Medicine at the University of Washington and the chief medical officer of supplement company Supergut