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Emerging evidence suggests a bidirectional relationship between gut health and brain function, often referred to as the gut-brain axis. Intestinal I/R injury, as a form of acute gut stress, has been implicated in triggering systemic inflammatory responses that extend beyond the gut, to impact distant organs, including the brain (Osadchiy et al., 2019)

Acupuncture is also used for pain management

However, the "top-down" approach only works if you use a high-bioavailability format