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doi: 10.3389/fped.2024.1344337 190 ClymanRIMaurayFRomanCHeymannMABallardPLRudolphAMet al

For exercise performance and VO2 max improvement, the evidence from human exercise studies suggests that MOTS-c's acute rise following high-intensity training is part of the adaptive signal driving mitochondrial biogenesis and cardiovascular remodeling