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The ATG8 lipidation machinery contains six ATG8 family proteins, which can be divided into two subfamilies: the microtubule-associated protein light chain 3 (LC3A, LC3B, LC3C) and gamma-aminobutyric acid receptor-associated protein (GABARAP, GABARAPL1, GABARAPL2) (6971)

This is important because unchecked oxidative stress is associated with so many diseases including cancers, neurodegenerative diseases such as Parkinsons and Alzheimers, and heart disease that it can aptly be considered a killer

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Pirman NL, Barber KW, Aerni HR, Ma NJ, Haimovich AD, Rogulina S, Isaacs FJ, Rinehart J (2015) A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation

This binding action triggers a complex intracellular signaling cascademost notably involving the PI3K/AKT pathwaythat ultimately prompts glucose transporter proteins (like GLUT4) to rise to the cell surface and pull glucose inside