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Description

Reduced Binding Protein Affinity: In the body, most IGF-1 is bound to a family of proteins known as IGF-binding proteins (IGFBPs)

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Pharmacological inhibition of LOX12/15 with PD146176 reduces ferroptosis in GPX4-deficient cells [42], and LOX inhibitors have been reported to suppress erastin-induced ferroptosis in certain experimental models [43]

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