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Yet, the enhancement in overall survival remains somewhat restricted [4]

10.1016/j.cell.2012.05.012 65

Because no single gold standard exists and agreement between tests is limited, reflecting assessment of different cognitive domains, test selection depends on locally validated norms and expertise [3, 4]

For information regarding different types of epidemiological studies, see the Spring/Summer 2016 LPI Research Newsletter

Moreover, a randomized, evaluator-blinded clinical trial including 40 Brazilian women with facial melasma who underwent broad-spectrum tinted sunscreen and nightly application of 5% cysteamine or 4% HQ for 16 weeks resulted in an MASI reduction of 32% and 52%, respectively [31]