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79 Chronic hyperglycemia activates mTORC1 and reduces mTORC2 activity 157 in islet cells, which leads to the translocation of FOXO1 to nucleus and less nuclear PDX1, resulting in reduced insulin synthesis and secretion and impaired cell mass 80,158 (Fig

All assays were conducted in triplicate, and all sample and standard solutions, as well as DPPH solutions, were freshly prepared daily (Scherer et al

Studies have shown that this peptide activates the enzyme called telomerase, which is responsible for telomere length extension

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The physicochemical properties of nanocarriers mainly include size and shape of nanocarriers, chemical composition (lipophilicity, biodegradability, pH), surface charge, and surface modification (Fig