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Armstrong JS, Jones DP

Adinolfi S, Patinen T, Deen AJ, Pitknen S, Hrknen J, Kansanen E, et al

In the second step, the homodimeric enzyme GS, a member of the ATP-grasp superfamily, rapidly catalyzes the binding of -glutamylcysteine with glycine, obtaining GSH (8, 9)

The dye is essentially non-toxic and once bound to DNA produces a stable fluorescent signal for up to 72 hours

The current review summarizes the most current examples of leishmanicidal agents based on 4-aminoquinolines focusing the analysis on two essential aspects: (i) structureproperty relationship to identify the key pharmacophores and (ii) mode of action focused on key targets in parasite survival ( e.g