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Xu X, Lin W, Liu T, Yuan C, Yan Y, Diao Y, et al

This group of cells is often implicated in inflammatory and degenerative disorders of the brain ( Classically the study of demyelination in disease has focused on oligodendrocytes, as those cells are primarily affected, but recent literature has shown an emerging role of other glial cells, particularly astrocytes and microglia, in regulating not only myelination but also neuroinflammation and neuroplasticity in the course of the disease ( As different mechanisms at a cellular level may be the cornerstone of developing more accurate biomarkers and effective DMTs, it is imperative to study the different influences which glial cells may exert in primary demyelinating phenotypes

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See the Experimental Phytotherapy paragraph for more in-depth studies

Activation of KEAP1/NRF2 stress signaling involved in the molecular basis of hemin-induced cytotoxicity in human pro-erythroid K562 cells