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Key Senomorphic Compounds and Their Mechanisms of Action Several compounds have been identified as potential senomorphics, each targeting different components of the SASP or senescence-associated signaling pathways

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Inhibition of AR-functions following treatment with the long living spontaneous NO-donor (Z)-1-[N-(2-Aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolat (DETA/NO) has recently been demonstrated [22]

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Moreover, JHU083 modulates MDSCs within the TME, promoting their polarization into pro-inflammatory TAMs and inhibiting the expression of IDO, thereby boosting the anti-tumor immune response [147]