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The theory is supported by both computational simulations of model proteins and experimental studies, [72] and it has been used to improve methods for protein structure prediction and design

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The role of CAR in promoting hepatocyte proliferation has been previously described in the literature ( Nr1i3 transcription and CAR activation downregulates the expression of APR genes in the liver, this finding appears somewhat contradictory

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In Arabidopsis, two genes each encode dual-targeted glutathione reductases (GR), and this is sufficient to explain the presence of GR activity in the chloroplasts, mitochondria, cytosol, and peroxisomes (Chew et al., K M value for NADPH below 10 M (Edwards et al., GR1 , encoding the cytosol/peroxisome enzymes, causes only moderate GSSG accumulation in leaf tissue, an observation explained by the existence of an auxiliary GSSG-reducing activity ensured by cytosolic NADPH-thioredoxin (TRX) systems (Marty et al., In contrast to GSSG reduction, the reactions that are most important in converting GSH to GSSG are less clear and, potentially, more complex