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In addition to conventional chemotherapeutics (e.g., doxorubicin, cisplatin, oxaliplatin, and 5-fluorouracil), targeted therapy drugs include kinase inhibitors (e.g., sorafenib, regorafenib, lenvatinib, and cabozantinib), immune checkpoint inhibitors (e.g., pembrolizumab, atezolizumab, and nivolumab), and angiogenesis inhibitors (e.g., ramucirumab and bevacizumab) and are currently used for systemic therapy in patients with HCC

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