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Zhang and C

Therapeutic Use in Pediatric Populations Clinical trials in children with idiopathic growth hormone deficiency showed therapeutic efficacy: Daily subcutaneous sermorelin 30 mcg/kg at bedtime significantly increased height velocity in prepubertal children Sustained growth acceleration maintained through 12-36 months of treatment in published studies Catch-up growth achieved in approximately 74% of treated children in 6-month trials Greatest responses observed in children with delayed bone age and lower baseline growth rates However, sermorelin required higher doses than initially anticipated and demonstrated lower potency compared to recombinant growth hormone, leading to commercial discontinuation despite proven safety

Nat Med 16:413419

Additionally, we introduced another histone H3 mutant, H3K18T, which mimics lactylation modification, into the cells

728 Conditional knockout of FPN1 in mouse endothelial cells (ECs) reduces the level of iron in the brain, oxidative stress, and ferroptosis after stroke, and finally reduces the volume of cerebral infarction and the nerve function injury in the acute stage of ischemic stroke