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If side effects emerge (injection site reactions, unusual symptoms), reduce dosage or frequency

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This conformation is maintained in part by autoinhibitory inter-subunit interactions between L1 and FnIII-2 in the dimer, and deletion of L1 leads to spontaneous activation of IGF1R

Galunisertib, a potent TGF-1 antagonist, has shown promising results when combined with gemcitabine in unresectable PDAC patients [145]

(3) high root-zone temperature treatment (HT): root-zone was heated to 35 1 C by heater stick