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Among them, oxidative stress is considered the cornerstone where cyclophosphamide elicits massive generation of ROS coupled with downregulating activities of antioxidant enzymes alongside Nrf2 pathway

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In addition, pharmaceuticals such as metformin have been shown to inhibit intestinal thiamine transporter, further contributing to thiamine deficiency (11)

It induces purified mitochondria to release the apoptogenic proteins cytochrome c and caspase-9

[PubMed Citation] Summary of clinical and non-clinical studies Exposure to chemical warfare agents (CWAs) may result in oxidative stress and subsequent acute lung injury and respiratory toxicity