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Moreover, evidence suggests that HIF-2 plays a role in maintaining CSC traits through the activation of WNT and NOTCH signaling 148 by elevating superoxide dismutase (SOD) levels and by reducing mitochondrial reactive oxygen species (ROS) levels 149

Oxidative stress measurement Antioxidant enzyme assays (for glutathione peroxidase [GPx], catalase, and SOD) were conducted to assess the stress levels of erythrocytes exposed to levofloxacin