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10.7554/eLife.45863 161 MaL.ZouR.ShiW.ZhouN.ChenS.ZhouH.et al (2022)

Owing to the severe adverse effects of TGF- inhibitors, Cu, often serving as a cofactor for metalloenzymes, can accelerate lung cancer progression, while Cu chelators can downregulate MMPs to reduce TGF- levels (Poursani et al., 2023)

Ravandi F, Alattar ML, Grunwald MR, Rudek MA, Rajkhowa T, Richie MA, Pierce S, Daver N, Garcia-Manero G, Faderl S, Nazha A, Konopleva M, Borthakur G , Burger J, Kadia T, Dellasala S, Andreeff M, Cortes J, Kantarjian H, Levis M

Self-catalyzed immobilization of GST-fusion proteins for genome-encoded biochips

However, due to the limited expression of ALT1/2 (or GPT1/2) and low transaminase activity, which restricts alanine biosynthesis, T cells need extracellular alanine for protein synthesis (135)