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no study has mapped these pathways in dogs, so any mechanism described here remains a hypothesis pending species-specific confirmation

SASPs enable the primary senescent cells to direct adjacent or distant nonsenescent cells to experience secondary senescence in autocrine, paracrine, and juxtacrine manners ( FIGURE 1 3 The association between renal senescence and CKD As mentioned above, renal ageing and senescence share numerous similarities with CKD in renal and systemic manifestations