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While the research discussed in this review focuses on the role of ferroptosis in cell death of tissues directly exposed to IR, there is evidence that ferroptosis plays a role in other systemic side effects of radiotherapy

A challenge test is often the third option if the former two are not possible or results are inadequate

Accordingly, A-exposed astrocytes stimulate an increase in endothelial TfR1 and DMT1 expression in patients brain regions vulnerable to AD pathology, such as the hippocampus and cortex, thereby potentially increasing transferrin-mediated iron uptake by endothelial cells [105]

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In addition, other investigations also indicated that probiotic can ameliorate hyperglycemia and dyslipidemia in DN patients