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Abstract Cellular senescence, driven by the interaction between FOXO4 and p53, is increasingly recognized as a crucial mechanism in brain aging and the development of neurodegenerative disorders

Within the toxicological community, it is generally accepted that, whereas the widely used analgesic and antipyretic drug acetaminophen ( N -acetyl- para -aminophenol) causes dose-dependent liver toxicity in humans and in various animal species, its regioisomer N -acetyl- meta -aminophenol (AMAP) does not

Additionally, vine tea total flavonoids (TFs) activate the AMPK/mTOR pathway to induce autophagy and modulate lipid metabolism-related proteins in HFD-fed mice, reducing de novo lipogenesis and regulating glycerophospholipid metabolism