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however, glucocorticoid-related mechanisms can cause iatrogenic stimulation of prostate cancer growth and/or resistance to ADT Abiraterone is an inhibitor of androgen synthesis that restrains androgen synthesis in the testes as well as prostate cancer cells, which has improved the outcomes of patients with prostate cancer Enzalutamide, an androgen receptor (AR) blocker, prevents androgen binding to the AR, thus reducing translocation of the androgenAR complex to the nucleus, inhibiting the expression of androgen target genes Abiraterone inhibits glucocorticoid synthesis while blocking androgen synthesis, and is usually given with a synthetic glucocorticoid to prevent adrenal insufficiency

Understanding this shared mechanism offers a rationale for therapeutic strategies targeting mitochondrial health and oxidative stress mitigation to alleviate tinnitus and potentially slow neurodegenerative progression (Teraoka et al., 2024

Toro-Roman A, Wu T, Stock AM

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PLoS One 8, e70690