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pylori ATCC 43504), while polyphenols and flavonoids such as quercetin, catechin, and luteolin inhibit urease and DNA gyrase act at MIC values of 1632, 64128 and 3264 g/mL, respectively (Huang et al., 2024)

The enzymes which have participated in these essential detoxification mechanisms comprise catalase, monodehydroascorbate reductase, superoxide dismutase, ascorbate peroxidase, glutathione reductase, dehydroascorbate reductase, guaiacol peroxidase [151]

Synthetic lethality was observed with loss of Fe-S cluster assembly genes, such as NFS1 cysteine desulfurase and HSPA9, and the Fe-S cluster transporter ATP binding cassette subfamily B member 7 (ABCB7), while the abrogation of mitochondrial Fe-S cluster-loading factors such as glutaredoxin 5 (GLRX5) and iron-sulfur cluster assembly factor IBA57 conferred resistance