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In vivo study: After treated with LW231 for 42 days in the AAV-HBV mice, the mean declines in HBV DNA was 0.2, 2.2 and 2.3 logs, in HBsAg was 0.3, 0.8, 0.5 logs, in HBeAg was 0.08, 1.1, 0.7 logs comparison to pretreatment levels in mice dosed with 50, 100 and 200 mg/kg LW231, respectively

These analgesic properties position DSIP as valuable research compound for developing non-opioid pain management strategies, understanding the relationship between sleep and pain processing, and investigating peptide-based approaches to chronic pain treatment

Statistical analyses were conducted using the GraphPad Prism 9.0 software suite

In patients with SLD, these integration sites predominantly occurred in intergenic regions (52.7%), followed by introns (43.7%) and exons (3.7%), which was consistent with observations in patients without SLD

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