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10 Conclusions and future directions Female reproductive disorders remain a major global health challenge, with limited innovative therapeutic options, underscoring the urgent need for multi-target agents capable of addressing the intertwined endocrine, metabolic, inflammatory, and fibrotic pathways that drive disease progression

The classic pencil-in-cup deformity, where the end of one bone erodes into a point and the adjacent bone cups around it, is pathognomonic for severe PsA

Supplementing with glutathione may help to counteract these effects, although more research is needed to fully understand its long-term benefits

Imidacloprid degraded to 85% of its measured concentration between the onset and the end (day 21) of the toxicity test