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Weeks 2-4: Appetite Effects Build, Early Weight Separation What the trials documented: Across the Phase 2 dose-finding trial, weight in the cagrilintide arms began separating from placebo during the initial weeks of titration, with the gap widening at every dose level as the study progressed (Lau et al., 2021)

CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation

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K.et al (2016)

Secretagogue studies often run over many weeks before measuring body composition changes