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Population doubling was calculated as below: Determination of infection conditions for CRISPR-pooled screen The Brunello CRISPR knockout library contains an average of 4 guides per gene for a total of 77,441 sgRNAs and 1000 control guides

N., Kwon, H

Unlike harmless commensal bacteria, microbial pathogens release an array of toxins or virulence factors that can alter cellular physiology and cause the release of DAMPs 1 , whose detection is instrumental in activating innate microbe-killing mechanisms