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17 While ERAD was previously thought to be associated with PQC, which safeguards protein maturation, recent studies have demonstrated that ERAD also regulates the abundance of folding-competent proteins as a means to fine-tune key physiological processes, suggesting that ERAD constitutively functions to ensure both protein fidelity and abundance

In concordance with lower superoxide levels, the levels of the intracellular antioxidant glutathione in its reduced form (GSH) also decreased dramatically (8-cell stage, p = 0.0023

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Freudenthaler SM, Schreeb KH, Wiese A, et al