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85 (3), 456462 (2020) K.

In summary, the accumulation of TMAO will not only increase oxidative stress and endothelial cell damage and permeability but also lead to an increase endothelial-derived NOS expression ( Vascular Calcification: TMAO Activates the NLRP3 Inflammasome and NF-B Signaling Pathway in Vascular Smooth Muscle Cells (VSMCs) Vascular calcification (VC) is a phenomenon of disseminated deposition of mineral content within the medial layer of arteries

PMID 9058374

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It is involved in the transport of long-chain fatty acids into the mitochondria, where they can be oxidized for energy production